Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 14/MAR/2004
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
1 - Product and Company Information
Product Name HEMATOXYLIN
Product Number H9627
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
HEMATOXYLIN 517-28-2 208-237-3 None
Molecular Weight 302.29 AMU
7,11b-dihydro-, (6aS-cis)- (9CI) * Haematoxylin
* (+)-Hematoxylin * Hydroxybrasilin *
Hydroxybrazilin * NCI-C55889
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes, respiratory system and skin.
4 - First Aid Measures
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
Directions for Safe Handling: Avoid breathing dust. Avoid
contact with eyes, skin, and clothing.
Conditions of Storage: Keep container closed. Store in a cool
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Slightly beige
Property Value At Temperature or Pressure
BP/BP Range N/A
MP/MP Range 200 藲C
Flash Point N/A
Autoignition Temp N/A
SIGMA - H9627 www.sigma-aldrich.com Page 2
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
Partition Coefficient N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Miscellaneous Data N/A
10 - Stability and Reactivity
Conditions of Instability: May discolor on exposure to light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
11 - Toxicological Information
RTECS NUMBER: MH7875000
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Inhalation: Material is irritating to mucous membranes and upper
Multiple Routes: May be harmful by inhalation, ingestion, or
skin absorption. Causes eye and skin irritation.
CHRONIC EXPOSURE - CARCINOGEN
Route of Application: Oral
Exposure Time: 26W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Blood:Lymphomas including Hodgkin's disease.
12 - Ecological Information
No data available.
13 - Disposal Considerations
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
SIGMA - H9627 www.sigma-aldrich.com Page 3
14 - Transport Information
Non-hazardous for road transport.
Non-hazardous for sea transport.
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritating to eyes, respiratory system and skin.
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
16 - Other Information
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
For R&D use only. Not for drug, household or other uses.
SIGMA - H9627 www.sigma-aldrich.com Page 4